Ras farnesyltransferase: a new therapeutic target

J Med Chem. 1997 Sep 12;40(19):2971-90. doi: 10.1021/jm970226l.
No abstract available

Publication types

  • Review

MeSH terms

  • Alkyl and Aryl Transferases*
  • Amino Acid Sequence
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Genes, ras
  • Growth Substances / physiology
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Neoplasms / genetics
  • Protein Prenylation*
  • Proto-Oncogene Proteins p21(ras) / genetics
  • Proto-Oncogene Proteins p21(ras) / metabolism
  • Signal Transduction
  • Transferases / antagonists & inhibitors
  • Transferases / metabolism*
  • ras Proteins / chemistry
  • ras Proteins / metabolism*

Substances

  • Enzyme Inhibitors
  • Growth Substances
  • Transferases
  • Alkyl and Aryl Transferases
  • p21(ras) farnesyl-protein transferase
  • Calcium-Calmodulin-Dependent Protein Kinases
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins